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Stanislav Jaracz
EDUCATION
2004 Ph.D., Organic Chemistry, Columbia University, NY.
Thesis: ¡°Bioorganic Studies on Ginkgolides¡±
Advisor: Professor Koji Nakanishi.
1997 M.S. Organic Chemistry, Charles University, Prague, Czech Republic.
Thesis: ¡°Enantioselective Addition of Diethylzinc to Aldehydes and Asymmetric Cyclopropanation¡±.
Advisors: Professor Pavel Kočovský and Stepan Vyskocil, Ph.D.
1995 B.Sc. Chemistry, Charles University, Prague, Czech Republic.
EMPLOYMENT
2004 ¨C present Postdoctoral Scientist, State University of New York at Stony Brook, NY.
Advisor: Prof. Iwao Ojima
¡¤ Synthesizing novel tumor-targeting taxoid conjugates.
¡¤ Synthesizing and in vitro evaluating of novel cleavable linkers for taxoid conjugates.
1998-2004 Graduate Research Assistant, Department of Chemistry, Columbia University, NY.
Advisor: Prof. Koji Nakanishi
¡¤ Developed efficient procedure for isolation of ginkgolides from G. biloba extracts.
¡¤ Performed solution and solid-phase synthesis of library of ginkgolide derivatives.
¡¤ Performed mechanistic studies of ginkgolide rearrangements.
¡¤ Synthesized photo-affinity probes of ginkgolides.
¡¤ Cultured mammalian cells overexpressing PAF receptor.
¡¤ Participated on PET animal studies with tritiated drug.
¡¤ Collaborated on SAR studies of ginkgolides with PAF receptor and Glycine receptor.
¡¤ Synthesized parts of retinol derivative for studies of retinol transferring proteins.
¡¤ Generated ~15,000-membered library of small receptor-like targets by means of split-and-pool solid-phase synthesis. Utilized binary encoding with halo-tags.
1999-2003: Graduate Teaching Assistant, Department of Chemistry, Columbia University, NY.
¡¤ Teaching undergraduate organic chemistry laboratory.
¡¤ Teaching at Columbia University Science Honors Program.
1995-1998 Research Assistant, Charles University, Prague, Czech Republic.
Advisors: S. Vyskocil Ph.D. and Prof. P. Kočovský
¡¤ Evaluated new binaphthyl ligands in asymmetric catalysis.
1997 summer internship, Ferring Pharmaceuticals, Prague, Czech Republic.
Supervisor: Martin Flegel, Ph.D.
¡¤ Tested new type of polystyrene resin. Synthesized oxytocine on a solid-phase.
SKILLS
Organic synthesis, handling air-, moisture- and light- sensitive materials, solid-phase chemistry.
Chromatography, HPLC, Gel Electrophoresis, 1D and 2D NMR, LC/MS, GC/MS, MS (EI, APCI), IR, UV, CD, Fluorometer, Fluorescent microscopy, ITC.
Microsoft Office, Microsoft FrontPage, Endnote, ChemDraw, Chem3D, SciFinder, CrossFire, MacroModel, PhotoShop, Gimp.
Development and maintenance of a research group website.
Languages: English, Czech and German, Russian, Polish.
AWARDS
2006: Ajinomoto Travel Award.
1999-2001: Alfred Bader Fellowship in Organic Chemistry, Columbia University.
1997: Talent of the Year Award, Ministry of Education, Czech Republic.
1992: Gold Medal Award, International Chemistry Olympiad, U.S.A.
1991: Bronze Medal Award, International Chemistry Olympiad, Poland.
ACTIVITIES
Member of the American Chemical Society, Division of Organic Chemistry.
LIST OF PUBLICATIONS
PATENTS
¡°Ginkgolide compositions and Ginkgo extracts for treatment of neurological disorders.¡± O.V. Vitolo, K. Nakanishi, M.L. Shelanski, S. Krane, O. Arancio, S. Jaracz, N.D. Berova. PCT Int. Appl. (2005), WO 2005092324, CA 143:373269.
¡°Separation of Ginkgolides and Bilobalide from Ginkgo Biloba Using Column Chromatography.¡± K. Nakanishi, S. Jaracz, S. Malik, H. Ishii, S. Dzyuba. PCT Int. Appl. (2005), WO 2005046829, CA 142:487413.
¡°Synthesis of Derivatives of Ginkgolide C for Use in Pharmaceutical Compositions as Glycine Receptor Antagonists.¡± K. Nakanishi, S. Jaracz, K. Strømgaard. PCT Int. Appl. (2005), WO 2005021496, CA 142:280326.
PAPERS
¡°Antibody-Cytotoxic Agent Conjugates for Cancer Therapy.¡± J. Chen, S. Jaracz, X. Zhao, S. Chen, I. Ojima Expert Opin. Drug Deliv. 2005, 2, 873.
¡°Recent Advances in Tumor-targeting Anticancer Drug Conjugates.¡± S. Jaracz, J. Chen, L. Kuznetsova, I. Ojima Bioorg. Med. Chem. 2005, 13, 5043.
¡°Isolation of Ginkgolides A, B, C, J and Bilobalide from G. biloba Extracts.¡± S. Jaracz, S. Malik, K. Nakanishi Phytochem. 2004, 65(21), 2897.
¡°Ginkgolides and Glycine Receptors. A Structure-Activity Relationship Study.¡± S. Jaracz, K. Nakanishi, A.A. Jensen, K. Strømgaard Chem. - A Eur. J. 2004, 10(6), 1507.
¡±Preparation of 7-Substituted Ginkgolide Derivatives: Potent Platelet Activating Factor (PAF) Receptor Antagonists¡± S. B. Vogensen, K. Strømgaard, H. Shindou, S. Jaracz, M. Suehiro, S. Ishii, T. Shimizu and K. Nakanishi J. Med. Chem. 2003, 46, 601.
¡°Ginkgolides: Selective Acetylations, Translactonization and Biological Evaluation¡± S. Jaracz, K. Strømgaard, K. Nakanishi, J. Org. Chem. 2002, 67, 4623.
¡°Synthesis of N-Alkylated Derivatives of 2-Amino-2¡¯-hydroxy-1,1¡¯-binaphthyl (NOBIN) and 2,2¡¯-Diamino-1,1¡¯-binaphthyl and Their Application in the Enantioselective Addition of Diethylzinc to Aromatic Aldehydes¡± S.Vyskocil, S.Jaracz, M.Smrcina, M.Sticha, V.Hanus, M.Polasek and P.Kočovský, J. Org. Chem. 1998, 22, 7727.
PRESENTATIONS
J. Chen, X. Zhao, S. Chen, S. Jaracz, I. Ojima. ¡°Synthesis and evaluation of a new class of disulfide-containing linkers for efficient intracellular release of anticancer agents.¡± 230th ACS National Meeting, Abstracts of Papers, Washington DC, August/September 2005.
S. Jaracz, K. Strømgaard, A.A. Jensen, K. Nakanishi. ¡°Combinatorial synthesis and biological evaluation of ginkgolide derivatives.¡± 226th ACS National Meeting, Abstr. Pap., New York, NY, September 2003.
S. Jaracz, K. Nakanishi, A.A. Jensen, K. Strømgaard. ¡°Ginkgolides from G. biloba and Glycine Receptors: Combinatorial Synthesis and Biological Evaluation.¡± The 2nd European Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials by ESCS, Copenhagen, Denmark, June 2003.
S. Jaracz, S. Vyskocil, P. Kočovský. ¡°Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using New Derivatives of 2-Amino-2¡¯-hydroxy-1,1¡¯-binaphthyl (NOBIN) and 2,2¡¯-Diamino-1,1¡¯-binaphthyl.¡± Conference of Czech Chemical Society, Liblice Castle, Czech Republic, 1998.
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