Dr. Xudong Geng

Ph.D., 2002

 

Education:

 

      09/1997 - 09/2002 Ph.D. candidate, Department of Chemistry, SUNY at Stony Brook.

        Major: Organic/Medicinal Chemistry

        Advisor: Iwao Ojima, Distinguished Professor and Chairman, Arthur C. Cope Scholar

 

   09/1992 – 07/1997 B.S., College of Chemistry & Molecular Engineering, Peking University.

        Major: Chemistry.

        Advisor: Chuanqiu Luo, Professor of Chemistry.

 

 

Research Interest:

 

     Discovery and development of new paclitaxel analogs: synthesis of advanced second-generation taxoids.

        Investigation of the bioactive binding conformation of palitaxel and its congeners by developing active macrocycle-constrained taxoids: Design and synthesis of conformationally restricted macrocyclic taxoids bearing tethers linking C-2 and C-3’N positions as well as taxoids bearing tethers linking C-2 and C-3’ positions using ring-closing metathesis reactions.

    Design and total synthesis of new generation of taxane-free anticancer agents: Designing scaffolds replacing taxane ring based on molecular modeling   

          studies; Total synthesis of scaffolds and de novo hybrids based on designed scaffolds.

 

WORK/RESEARCH EXPERIENCE

 

i.    02. 1999 - present Graduate Research Assistant, Department of Chemistry, SUNY at Stony Brook

ii.    09. 1997 - 02, 1999 Graduate Teaching Assistant, General Chemistry, Department of Chemistry, SUNY at Stony Brook

iii.   09. 1996 - 06. 1997 Senior Undergraduate Research Assistant, Department of Polymer Chemistry, Peking University.

AFFILIATIONS

1998- present               Member, American Chemical Society (incl. Medicinal Chemistry Division).

 

PUBLICATIONS

  1. Ojima, I.; Lin, S.; Inoue, T.; Miller, M. L.; Borella, C. P.; Geng, X.; Walsh, J. J. J. Am. Chem. Soc. Macrocycle Formation by Ring-Closing Metathesis. Application to the Syntheses of Novel Macrocyclic Taxoids, 2000, 122, 5343-5353.

  2. Lin, S.; Geng, X.; Qu, C.; Tynebor, R.; Gallagher, D. J.; Pollina, E.; Rutter, J.; Ojima, I. Chirality Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic b -lactams with baccatins, 2000, 12, 431-441.

  3. Ojima, I.; Wang, T.; Miller, M. L.; Lin, S.; Borella, C. P.; Geng, X.; Pera, P.; Bernacki, R. J. Bioorg. Med. Chem. Lett. Synthesis and structure-activity relationships of new second-generation taxoids, 1999, 9, 3423-3428.

  4. Crabtree, D. V.; Ojima, I.; Geng, X., Adler, A. J. Bioorg. Med. Chem. Tubulins in the Primate Retina: Evidence That Xanthophylls are Endogenous Ligands for the Paclitaxel-Binding Site, 2001, 9, 1967-1976.

    5. Chibale, K.; Ojima, I.; Haupta, H.; Geng, X.; Pera, P.; Bernacki, R. J. Bioorg. Med. Chem. Lett. Modulation of Human Mammary Cell Sensitivity to Paclitaxel by New 

        Quinoline Sulfonamides, Bioorg. Med. Chem. Letts, 2001, 11, 2457-2460.        

 

PRESENTATIONS

  1. Wang, T.; Lin, S.; Wu, X.; Geng, X.; Ojima, I. 221st ACS National Meeting, San Diego, CA, April 1-5 2001 Synthesis of amino/aza-sugers and their derivatives through efficient ring expension of b-lactams, 2001, CARB-057.

  2. Geng, X.; Borella, C. P.; Li, D.; Lin, S.; Pera, P.; Bernacki, R. J.; Ojima, I. 221st ACS National Meeting,.San Diego, CA, April 1-5 2001 Design and synthesis of de novo macrocyclic hybrids as potential anticancer agents, 2001, 221st, MEDI-130..

  3. Wang, T.; Lin, S.; Wu, X.; Geng, X.; Ojima, I. 220st ACS National Meeting Washinton D.C. August 20-24 2000 New and efficient routes to amino/aza-sugars and their derivatives, 2000, ORGN-066.

  4. Miller, M. L.; Geng, X.; Lin, S.; Pera, P.; Bernacki, R. J.; Ojima, I. 220st ACS National Meeting Washinton D.C. August 20-24 2000 Biological activity and SAR of novel macrocyclic taxoids, 2000, MEDI-036.

  5. Lin, S.; Geng, X.; Qu, C.; Tynebor, R.; Gallagher, D.; Ojima, I. 220st ACS National Meeting Washinton D.C. August 20-24 2000 Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic b-lactams with baccatins, 2000, ORGN-061.

  6. Geng, X.; Miller, M. L.; Lin, S.; Pera, P.; Bernacki, R. J.; Ojima, I. 220st ACS National Meeting Washinton D.C. August 20-24 2000 Design and synthesis of novel macrocycle-constrained taxoids, 2000, ORGN-445.

  7. Geng, X.; Miller, M. L.; Lin, S.; Pera, P.; Bernacki, R. J.; Ojima, I. 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000 Design, synthesis, and biological activity of novel macrocyclic taxoids as potential anticancer agents, 2000, MEDI-021.

  8. Wang, T.; Lin, S.; Wu, X.; Geng, X.; Ojima, I. 218th ACS National Meeting, New Orleans, LA, Aug. 22-26 1999 New, efficient routes to aminosugars and azasugars, and their derivatives, 1999, ORGN-385.

  9. Wang, T.; Miller, M.; Borella, C.; Lin, S.; Geng, X.; Pera, P.; Bernacki, R. J.; Ojima, I. 218th ACS National Meeting, New Orleans, LA, Aug. 22-26 1999 Syntheses and biological activity of advanced second-generation taxoids, 1999, MEDI-038.

    10. Geng, X.; Borella, C. P.; Miller, M. L.; Lin, S.; Chakravarty, S.; Ojima, I. 218th ACS National Meeting, New Orleans, LA, Aug. 22-26 1999 Design and synthesis of novel macrocyclic taxoids. 1999, ORGN-150.

 

My Hotlink

 

http://www.sinc.sunysb.edu/stu/xgeng

 

 

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