Dr. Greta Varchi

 

Education

Since 12/2001        Permanent position as 3rd level researcher at the National                                        Research Council, research area of Bologna, Italy.

 

October/2001         Doctorate in Chemistry Sciences, University Of Bologna, Italy.

 

 

 

10/1998-10/2001     Dissertation, Department of Organic Chemistry “A. Mangini”, University of Bologna, in the group of Prof. A. Ricci ,and 6 months at the Department of Organic Chemistry of the Ludwig Maximillinans University of Munich (Germany) in the group of Prof. P. Knochel.

 

Title of the Doctoral Thesis:“Stereo-defined, hetero-substituted molecules, as building blocks for the synthesis of biologically active compounds, and ligands for asymmetric catalysis”. 

 

01/1998-07/1998     Visiting researcher at the Department of Organic                                   Chemistry of the Fachbereich Chemie (Marburg, Germany)

 

 

 

07/1997        Laurea in Industrial Chemistry (108/110), University of Bologna,                            Department of Organic Chemistry.

 

Title of the Laurea Thesis: “Synthesis and reactions of homochiral a- and b-aminoacylsilanes “

10/1991-07/1997     University Education in organic, inorganic, physical and industrial                              chemistry, Mathematics. (University Of Bologna, Italy).

 

 

Selected Accomplishments

Development  of a methodology for the synthesis of a- and b-aminoacylsilanes, based on a nucleophilic sylilation reaction using a polymetallic reagent. Transformation of these compounds in biologically active products as poliaminossidrilated compounds, statines and iso-statines analogous, b- and g-aminoalcohols.

Synthesis of chiral ligands for asymmetric catalysis, starting from natural a-aminoacids.

 

Development of a new methodology for the preparation of aromatic and heteroaromatic polyfunctionalized Grignard reagents, via a halogen-Mg exchange.

Instruction and supervision of undergraduate students in theory and practice of Organic Chemistry.

Supervisor of four Laurea students.

 

Publications

 

1)       B. F. Bonini, M. Comes Franchini, M. Fochi, G. Mazzanti, A. Ricci, G. Varchi. “A Convenient Conversion of a-Aminoacids into NH-Boc Protected a-Aminoketones via Imidazolides”. Synlett, 1998, 1013-1015.

 

2)       B. F. Bonini, M. Comes-Franchini, M. Fochi, G. Mazzanti, A. Ricci, G. Varchi. “New chiral allylaminosilanes and their use in asymmetric Sakurai reactions” Tet. Asym., 1998, 2979-2981

 

3)       B. F. Bonini, M. Comes Franchini, M. Fochi, G. Mazzanti, A. Ricci, G. Varchi. “Synthesis of Enantiopure Dichiral b- and g-Amino Alcohols from Homochiral a- and b-Amino Acylsilanes as stable Synthetic Equivalents of a- and b-Amino Aldehydes” Eur. Journal of Organic Chemistry, 1999, 437-445.

 

4)       B. F. Bonini, M. Comes Franchini, M. Fochi, G. Mazzanti, A. Ricci, G. Varchi “Extremely facile formation and high reactivity of new thioacylsilane containing the ferrocene moiety” Tetrahedron Lett. 1999, 40, 6473-6476.

 

5)       B. F. Bonini, M. Comes Franchini, M. Fochi, Fréderic Laboroi, G. Mazzanti, A. Ricci, G. Varchi “Stereoselective three-carbon and two-carbon elongation of the carbon chain in N-Boc-protected a-aminoacylsilanes: an entry to functionalized b-amino alcohols and to statine analogues” J. Org. Chem. 1999, 64, 8008-8013.

 

6)       G. Varchi, A. Ricci, G. Cahiez, P. Knochel “Copper catalysed conjugate addition of highly functionalized arymagnesium compounds to enones” Tetrahedron 2000, 56, 2727-2731.

 

7)       B. F. Bonini, M. Comes Franchini, M. Fochi, G. Mazzanti, A. Ricci, G. Varchi “Sylilcupration of acylimidazolides. A new synthesis of a-aminoacylsilanes and their synthetic applications” Polyhedron 2000, 19, 529-531.

 

8)       B. F. Bonini, M. Comes Franchini, M. Fochi, G. Mazzanti, A. Ricci, G. Varchi “Cerium(III) chloride –mediated vinylation of acylsilanes: a convenient new entry to sylilated allylic alcohols” Synlett 2000, 11, 1688-1690.

 

9)       Rottlaender M., Boymond L., Berillon L., Lepretre A., Varchi G., Avolio S., Laaziri H., Queguiner G., Ricci A., Cahiez G., Knochel P., “New polyfunctionalized magnesium reagents for organic synthesis” Chem.Europ.J. 2000, 6, 767-770. 

 

10)   Varchi G., Jensen A. E., Dohle W., Ricci A., Cahiez G., Knochel P. “Preparation of functionalized magnesiated aniline derivatives” Synlett 2001, 4, 477 – 480.

 

11)   B. F. Bonini, M. Comes Franchini, M. Fochi, L. Lunazzi, A. Mazzanti, G. Mazzanti, A. Ricci, G. Varchi “Diastereoselective synthesis of diamino 1,2-diols from homochiral a-aminoacylsianles” Synlett 2001, 995-998.

 

12)   B. F. Bonini, C. Femoni, M. Comes Franchini, M. Fochi, G. Mazzanti, A. Ricci, G. Varchi “One pot synthesis of new b-lactams containing the feroccene moiety” Synlett 2001, 7, 1092-1096.

 

13)   M. C. Daga, M. Taddei, G. Varchi “Rapid microwave.-assisted deprotection of N-Cbz and N-.Bn derivatives” Tetrahedron Lett. 2001, 42, 5191-5194.

 

14)   G. Varchi, C. Kofink, D. M. Lindsay, A. Ricci, P. Knochel “Direct Preparation of Polyfunctional Amino-Substituted Arylmagnesium via an Iodine-Magnesium Exchange Reaction” , submitted for publication. 

 

15)   Bonini, B. F.; Comes-Franchini, M.; Fochi, M.; Mazzanti, G.; Ricci, A.; Tomasulo, M.; Varchi, G., J. Organomet. Chem., 2001, 637, 407-417. 

 

16)   Bernardi, L.; Bonini, B. F.; Dessole, G.; Fochi, M.; Comes-Franchini, M.; Gavioli, S.; Ricci, A.; Varchi, G..  “Concise and Stereocontrolled Synthesis of Pseudo-C2-symmetric Diamino Alcohols and Triamines for Use in HIV Protease Inhibitors”  J. Org. Chem., 68, 2003, 1418-1425.

 

Conferences Attended

1)   ICOS-12: 12th International Conference on  Organic Synthesis (Venezia, 28/2-07 1998: “Synthesis of Enantiopure Dichiral b- and g-Amino alcohols from homochiral a- and b-amino acylsilanes. Poster Communication.

 

2)       BONYMI VI (Nijmegen, Holland) 14/18-09 1998: “Two interesting applications of functionalized Grignard reagents”  Oral Communication.

 

3)       10th IUPAC Symposium on Organo-Metallic Chemistry directed towards Organic Synthesis (Versailles, France 18/22-07 1999: ”3-Carbon and 2-carbon Elongation of the Carbon Chain in N-Boc-Protected a-Amminoacylsilanes: an Entry to Functionalized b-Aminoalcohols and to statine Analogues”. Poster Communication.

 

4)       XXVI Italian Congress of the Organic Chemistry (Catania 1/5-09 1999) Addizioni coniugate di reagenti di Grignard altamente funzionalizzati di enoni, catalizzate da rame. Poster Communication.

 

5)       ISOCS-19: 19th International Symposium of the Organic Chemistry of Sulfur (Sheffield, UK 25/30-06 2000): Thioferrocenoylsilanes as Useful Building Blocks for organic Synthesis. Poster Communication.

 

6)       Stereoselection Organic Chemistry Italian Symposium (Camerino 3/5-12 2000). Synthesis of Polidentated ligands for asymmetric homo- and heterogeneous catalysis. Oral Communication.