Liang Sun

Ph.D. 2008

 

Education: 

  Ph.D. in Organic/Medicinal Chemistry  

Department of Chemistry 

State University of New York at Stony Brook, 2002 - 2008

Advisor: Dr. Iwao Ojima

Thesis title: Design, synthesis, biological evaluation and molecular modeling of novel taxane-based anticancer agents and paclitaxel mimics

  B.S. in Chemistry  

Department of Chemistry

Nankai University, China, 1998 - 2002.

 

Research Interest: 

·        Synthesis of Tumor-Activated Prodrug (TAP) 

·        Synthesis of Macrocyclic Taxoids

·        Design and Synthesis of de novo Paclitaxel Mimics

·        Molecular modeling (quantum mechanics, molecular mechanics, molecular dynamics simulation, de novo design and docking)

·        Cytotoxicity assay (MTT, MTS and SRB)

 

Teaching Experience:

·        Teaching Assistant, General Chemistry (CHE 131 & CHE 132), SUNY at Stony Brook, 2002-2003

 

Affiliations:

·        American Chemical Society

·        Sigma Xi, the Scientific Research Society

·        American Association for the Advancement of Science

ACS Presentations:  

(1) Chen, J.; Kuznetsova, L.; Sun, L.; Zhao, X.; Wu, X.; Huang, Q.; Chibale, K.; Clarkson, C.; Smith, P.; Croft, S. L.; Ojima, I. “Design, synthesis, and evaluation of taxanes as potential antimalarial agents.” Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003, MEDI-259.

(2) Kuznetsova, L; Wu, X; Chen, J; Pepe, A; Sun, L.; Veith, J. M.; Bernacki, R. J.; Ojima, I.  Synthesis and evaluation of novel fatty acid-2nd-generation taxoid conjugates as promising anticancer agents. Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA, United States, March 28-April 1, 2004, MEDI-110.

(3) Sun, L.; Geney, R.; Geng, X.; Ojima, I. “Rational design, synthesis and evaluation of conformationally restrained novel paclitaxel analogs.” Abstracts of Papers, 228th ACS National Meeting, Philadelphia, PA, United States, August 22-26, 2004, MEDI-097.  

(4) Sun, L.; Geney, R.; Li, Y.; Ma, K; Ojima, I. “Design, synthesis and evaluation of novel macrocyclic paclitaxel analogs and a de novo paclitaxel mimic.” Abstracts of Papers, 230th ACS National Meeting, Washington , DC , United States , Aug. 28-Sept. 1, 2005, MEDI-354.

(5) Sun, L.; Ojima, I. “Design and synthesis of de novo paclitaxel mimics.” Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006, ORGN-851.

(6) Sun, L.; Ojima, I. “Design and synthesis of de novo paclitaxel mimics based on REDOR-Taxol structure.” Abstracts of Papers, 40th Middle Atlantic Regional Meeting, New York, NY, United States, May. 17-21, 2008, MRM-158.

Publications:

(1) Geney, R.; Sun, L.; Pera, P.; Bernacki, R. J.; Xia, S.; Horwitz, S. B.; Simmerling, C. L.; Ojima, I. “Use of the tubulin bound paclitaxel conformation for structure-based rational drug design.” Chem. Biol., 2005, 12, 339-348.

(2) Kuznetsova, L.; Chen, J.; Sun, L.; Wu, X.; Pepe, A.; Veith, J. M.; Pera, P.; Bernacki, R. J.; Ojima, I. “Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.” Bioorg. Med. Chem. Lett., 2006, 16, 974-977.

(3) Ojima, I.; Kuznetsova, L.; Sun, L. “Organofluorine chemistry at the biomedical interface – A case study on fluoro-taxoid anticancer agents.” In “Current Fluoroorganic Chemistry: New Synthetic Directions, Technologies, Materials, and Biological Applications”; ACS Symp. Ser. 949; American Chemical Society: Washington, D.C., 2006, pp 288-304.

(4) Chiou, W.-H.; Schoenfelder, A.; Sun, L.; Mann, A.; Ojima, I.  “Rhodium catalyzed cyclohydro-carbonylation approach to the syntheses of enantiopure homokainoids.”  J. Org. Chem., 2007, 72, 9418-9425.

(5) Ojima, I.; Chen, J.; Sun, L.; Borella, C. P.; Wang, T.; Miller, M. L.; Lin, S.; Geng, X.; Kuznetsova, L.; Qu, C.; Gallager, D.; Zhao, X.; Zanardi, I.; Xia, S.; Horwitz, S.B.; Clair, J. M.; Guerriero, J. L.; Bar-Sagi, D.; Veith, J. M.; Pera, P.; Bernacki, R. J.. “Design, synthesis and biological evaluation of new-generation taxoids.” J. Med. Chem. 2008, 51, 3203-3211.

(6) Sun, L.; Geng, X.; Geney, R.; Li, Y.; Simmerling, C.; Li, Z.; Lauher, J. W.; Xia, S.; Horwitz, S. B.; Veith, J. M.; Pera, P; Bernacki, R. J.; Ojima, I. “Design, synthesis, and biological evaluation of novel C14-C3’BzN-linked macrocyclic taxoids.” J .Org. Chem. 2008, 73, 9584-9593.

(7) Pepe, A; Kuznetsova, L; Sun, L.; Ojima, I. “Fluoro-taxoid anticancer agents.” In “Fluorine in Medicinal Chemistry and Chemical Biology.” Wiley-Blackwell, Chichester, 2009, pp 117-139.

(8) Sun, L.; Simmerling, C.; Ojima, I. Recent advances in the study of the bioactive conformation of Taxol. ChemMedChem 2009, 4, 719-731.

(9) Pepe, A; Sun, L.; Zanardi, I.; Wu, X.; Ferlini, C.; Fontana, G.; Bombardeli, E.; Ojima, I. “Novel C-seco-taxoids possessing high potency against paclitaxelresistant cancer cell lines overexpressing class III β-tubulin.” Bioorg. Med. Chem. Lett. 2009, 19, 3300-3304.

 

Interests:

Photography, Soccer, Reading, Video Games, Movies, and Music.

     

 

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