Ph.D., 1999

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EDUCATION

08. 1994 - present Ph.D. candidate (expected completion date: August 1999), Department of Chemistry, SUNY at Stony Brook.

Major: Organic/Medicinal Chemistry

Advisor: Professor Iwao Ojima

08. 1989 - 06.1994 B.S., Department of Applied Chemistry, University of Science and Technology of China (USTC). GPA: 3.9

Major: Analytical Chemistry

08. 1983 - 06. 1989 Graduation Certificate, The No. 1 Middle School of Putian, Fujian, China

RESEARCH INTERESTS

• Discovery and development of new and potent taxoid ( = Taxol® analogs) and non-taxoid anticanceett. Submitted.

PRESENTATIONS/CONFERENCES/SYMPOSIUMS

1. Lin, S.; Inoue, T.; Chakravarty, S.; Ojima, I. "Design and Synthesis of Taxoid-Epothilone Hybrids. Part I." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORGN 464.

2. Inoue, T.; Lin, S.; Walsh, J. J.; Borella, C.; Chakravarty, S.; Ojima, I. "Design and Synthesis of Taxoid-Epothilone Hybrids. Part II." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORGN380.

3. Lin, S.; Slater, J. C.; Pera, P.; Bernacki, R. J.; Scambia, G.; Ojima, I. "Syntheses and Biological Activity of Advanced Second-Generation Taxoids." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. MEDI 315.

4. Brey, R.; Lin, S.; Walsh, J. J.; Cresteil, T.; Ojima, I. "The Synthesis of Novel Fluorinated Paclitaxel and Docetaxel Analogs Designed to Inhibit Metabolism by Cytochrome P-450 Enzymes." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. MEDI 312.

5. Lin, S.; Inoue, T.; Borella, C.; Walsh, J. J.; Chakravarty, S.; Ojima, I. "Design and Structure-Activity Relationship Study of Taxoid-Epothilone Hybrids." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. MEDI 313.

6. Lin, S.; Wang, T.; Ojima, I. "New and Efficient Route to the Polyfunctionalized Heterocycles. I. Stereocontrolled Syntheses of g(d)-Lactones." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORGN 560.

7. Wang, T.; Bounaud, P.-Y.; Lin, S.; Ojima, I. "New and Efficient Route to the Polyfunctionalized Heterocycles. I. Stereocontrolled Syntheses of g(d)-Lactams." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORGN 559.

8. Ojima, I.and Lin, S. "Highly Efficient Asymmetric Syntheses of b-Lactams Bearing a Cyclopropane or an Epoxide Moiety and Their Facile Conversion to Novel Isoserines, Dipeptides and Taxoids." New York Academy of Sciences Poster Program for Graduate Students of Chemistry, November 1997; New York City, New York; Abstr.

9. Lin, S. and Ojima, I. "Highly Efficient Asymmetric Syntheses of Novel Norstatine Analogs Bearing Cyclopropane and Oxirane Moieties." 214th American Chemical Society National Meeting, September 7-11, 1997, Las Vegas, Nevada; Abstr. ORGN 211.

10. Ojima, I.; Lin, S.; Pera, P.; Veith, J. M.; Bernacki, R. J. "Syntheses and Biological Activities of New Taxoids Bearing Methano- and Oxirano-Isoserine Residues at C-13." 214th American Chemical Society National Meeting, September 7-11, 1997, Las Vegas, Nevada; Abstr. MEDI 76.

11. Ojima, I.; Lin, S.; Pera, P.; Veith, J. M.; Bernacki, R. J. "Synthesis and Structure-Activity Relationship Study of Novel Nor-Seco Taxoids with a C-13 Amide Linkage." New York Academy of Sciences Poster Program for Graduate Students of Chemistry, November 1996; New York City, New York; Abstr.