Dr. Michael L. Miller
Postdoctoral Research Associate
State University of New York at Stony Brook
Department of Chemistry
Stony Brook, NY 11794
Phone: (516) 632-7824
Fax: (516) 632-7942
E-mail: mlmiller@ccnova.sunysb.edu
EDUCATION:
October 1998 - present
Postdoctoral Research Associate in the Department of Chemistry at the State University of New York at Stony Brook. Stony Brook, NY
August 1994 - August 1998
Ph.D. in Organic Chemistry from the University of Memphis. Memphis, TN.
Dissertation: Synthesis of Pyrimidoazepine-Based Folates and Progress Towards the Synthesis of Novel Taxoids as Potential Antitumor Agents.
August 1990 - May 1994
B.S. in Chemistry (magna cum laude) from Memphis State University. Memphis, Tennessee.
HONORS:
Fall 1997 - Spring 1998
Recipient of American Chemical Society, Division of Medicinal Chemistry, Predoctoral Fellowship (Sponsored by Bristol-Meyers-Squibb).
EXPERIENCE:
Fall 1994 - Spring 1997
Graduate Teaching Assistant at the University of Memphis, teaching five sections of Organic Chemistry per year.
Fall 1993 - Spring 1994
Undergraduate research for Dr. C.N. Robinson. Studies on the Knoevenagel reaction of aromatic aldehydes with diethyl-phosphono acetonitrile: their anti- HIV and NMR properties. Memphis State University. Memphis, Tennessee.
RESEARCH INTERESTS:
Multi-step synthesis of challenging molecules with potential medicinal value. Heterocyclic chemistry. NMR interpretation and various related disciplines. Rational design of new targets based on molecular modeling studies
MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS:
American Chemical Society
ACS Division of Medicinal Chemistry
ACS Division of Organic Chemistry
PUBLICATIONS:
Miller, M. L.; Ray, P. S. Synthesis of 5-Amino-9-benzyl-6-formyl-4-methoxy-2-pivaloylamino-7,8-dihydropyrimido [4,5-b]azepine. A Potentially Useful Intermediate Towards the Synthesis of Pyrimidoazepine Based Folic Acid Derivatives. J. Het. Chem., 1996, 33, 259-263.
Miller, M. L.; Ray, P. S. An Intramolecular 1,3-Dipolar Cycloaddition Approach to a Pyrimidoazepinone Derivative. A Potentially Useful Intermediate Towards the Synthesis of Pyrimidoazepine-Based Folic Acid Derivatives. Tetrahedron, 1996, 52, 5739-5744.
Miller, M. L.; Ray, P. S. Synthesis of 4-[8-Amino-6-benzyl-10(9H)-oxo-4,5-dihydro-(6H)-isoxazolo[4,3-d]pyrimido [4,5-b]azepine- 3-yl]benzoyl-L-glutamic Acid. A Novel Pyrimidoazepine Based Folic Acid Derivative. Heterocycles, 1996, 45, 501-506.
Miller, M. L.; Ray, P. S. A Convenient Synthesis of 2,2,4-Trimethyl-cyclohexane-1,3-dione: A Useful Precursor for the Taxoid A Ring. Syn. Comm., 1997, 27, 3991-3996.
Miller, M. L.; Ray, P. S; Read, Mark W. Synthesis of N-{[4-(2-Amino-4(3H)-oxo-5,6,7,8-tetrahydro-(9H)-pyrimido [4,5-b]azepin-6-yl)methyl]benzoyl-L-glutamic Acid and two of its Conformationally-Restricted Analogs. Tetrahedron, 1999, 55, 373-392.
PRESENTATIONS:
March 1993
Synthesis of Anti-HIV Agentsî 13th Annual Undergraduate Chemical Research Conference. Memphis State University. Memphis, TN.
October 1996
Synthesis of Pyrimidoazepine-Based Folic Acid Derivatives as Potential Antitumor Agents: A 1,3-Dipolar Cycloaddition Approachî ACS 52nd Southwest Regional Meeting. Houston, TX.
December 1996
NMR: Application and Interpretation in the Biomedical Sciencesî Biomedical Research Techniques: A Workshop. University of Memphis. Memphis, TN.
June 1997
Synthesis of Pyrimidoazepine-Based Tetrahydrofolic Acid Derivatives as Potential Inhibitors of Glycinamide Ribonucleotide Formyl-transferase: A 1,3-Dipolar Cycloaddition Approach 35th National Organic Symposium. San Antonio, TX.
October 1997
Synthesis of Pyrimidoazepine-Based Tetrahydrofolic Acid Derivatives as Potential Inhibitors of Glycinamide Ribonucleotide Formyl-transferase: A 1,3-Dipolar Cycloaddition ApproachACS 53rd Southwest Regional Meeting. Tulsa, OK.
June 1998
Synthesis and Antitumor Properties of Pyrimidoazepine-Based Tetrahydrofolic Acid Derivativesî 26th National Medicinal Chemistry Symposium. Richmond, VA.
August 1998
Synthesis and Antitumor Properties of Pyrimidoazepine-Based Tetrahydrofolic Acid Derivativesî 216th ACS National Meeting. Boston, MA.