Dr. Pierre-Yves Bounaud
Ph.D, 1998

Education

B.Sc. degree in Chemical Engineering in 1994 from Ecole Supérieure de Chimie Industrielle de Lyon, Lyon, France.

Ph.D. 1992-1998.

Research Interests:

• Organic synthesis and medicinal chemistry

• Synthesis of biologically active molecules

Previous Research:

• Synthesis of steroidal polyamines and their application to gene therapy.

Publications

• “Structural Requirements of Taxoids for Nitric Oxide and Tumor Necrosis Factor Production by
Murine Macrophages” Biochem. Biophys. Res. Com. 1996, 227, 227.

• “Syntheses and Structure-Activity Relationships of the Second-Generation Antitumor Taxoids:
Exceptional Activity against Drug-Resistant Cancer Cells” J. Med. Chem. 1996, 39, 3889.

• “New Taxanes as Highly Efficient Reversal Agents for Multi-Drug Resistance in Cancer Cells”, I.
Ojima, P.-Y. Bounaud, C. Takeuchi, P. Pera, and R. J. Bernacki Bioorg. Med. Chem. Lett.. 1998, 8,
189.

Presentations:

• “Syntheses of New Photoreactive Analogs of Paclitaxel”, I. Ojima and P.-Y. Bounaud. 212th ACS
National Meeting, Orlando, Florida (Poster).

• “New Taxanes as Highly Efficient Reversal Agents for Multi-Drug Resistance in Cancer Cells”, I.
Ojima, P.-Y. Bounaud, C. Takeuchi, P. Pera, and R. J. Bernacki. 213th ACS National Meeting, San
Francisco, California (Poster).

• “Synthesis and Evaluation of New Taxane-Based Reversal Agents”, I. Ojima, P.-Y. Bounaud, P. Pera,
and R. J. Bernacki. 213th ACS National Meeting, San Francisco, California (Poster).

• “New Paclitaxel Photoaffinity Labels to Probe the Binding Site on the Multidrug Transporter
P-Glycoprotein”, Q. Wu, P.-Y. Bounaud, S. D. Kuduk, C.-P. H. Yang, I. Ojima, S. B. Horwitz, G. A. Orr.
215th ACS National Meeting, Dallas, Texas (Poster).

• “Structure-Activity Relationship Studies of New Taxanes as Reversal Agents for Multidrug Resistance
in Cancer Cells”, I. Ojima, P.-Y. Bounaud, C. Takeuchi, C. Liang, S. M.-G. Eppich, P. Pera, R. J. Bernacki.
215th ACS National Meeting, Dallas, Texas (Oral).


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