Dr. Subrata Chakravarty
Dr. Subrata Chakravarty
EDUCATION
1997 Ph. D. (Organic/Medicinal Chemistry), State University of New York at Stony Brook, Stony Brook, NY.
1992 Ph. D. (Agricultural Chemicals), Indian Agricultural Research Institute (IARI), New Delhi, India.
1989 M. Sc. (Soil Science and Agricultural Chemistry), IARI, New Delhi, India.
1987 B. Sc. (Chemistry, Honours), St. Stephen's College, Delhi
University, Delhi, India.
WORK/RESEARCH EXPERIENCE
1997-present Postdoctoral Associate, Department of Chemistry, SUNY at Stony Brook.
1997-1998 Postdoctoral Lecturer, Department of Chemistry, SUNY at Stony Brook.
1993-97 Project Research Assistant, Department of Chemistry, SUNY at Stony Brook.
1993-96 Graduate Assistant (Nuclear Magnetic Resonance Facility), SUNY at Stony Brook.
1992-93 Teaching Assistant (General Chemistry), SUNY at Stony Brook.
1989-92 Senior Research Fellow, IARI, New Delhi, India.
1987-89 Junior Research Fellow, IARI, New Delhi, India.
AWARDS/AFFILIATIONS/APPOINTMENTS
Awards and Scholarships:
Travel Award, American Peptide Society (1995)
Senior Research Fellowship, IARI, New Delhi, India (1989-92)
Junior Research Fellowship, IARI, New Delhi, India (1987-89)
National Talent Search (NTS) Scholarship, National Council of Educational Research and Training (NCERT), New Delhi, India (1984-87)
Presenter, Minisymposium at the 14th American Peptide Society Meeting, Columbus, Ohio (1995)
Society Affiliations: Member, American Association for the
Advancement of Science (1998-); American Chemical Society (1993-);
American
Peptide Society (1995-); Federation of Associations for Structural
and Experimental Biology (1996-)
MAJOR RESEARCH INTERESTS
Design, synthesis, SAR and QSAR of compounds of medicinal and agricultural importance, including antitumor, antithrombotic, crop protection and antiinfective agents.
Solid and solution-phase methodology in organic chemistry: applications to combinatorial chemistry, peptide and peptidomimetic chemistry.
NMR and computer-aided drug design: Use of NMR and computational
tools in medicinal chemistry, pharmacophore discovery.
PUBLICATIONS
1. Ojima, I.; Chakravarty, S.; Inoue, T.; Lin, S.; Horwitz, S.
B.; Kuduk, S. D.; Danishefsky, S. J. (1999) A Common Pharmacophore for
Cytotoxic Natural Products that Stabilize Microtubules, manuscript
in preparation.
2. Ojima, I.; Lin, S.; Inoue, T.; Chakravarty, S. (1999) Design and Synthesis of Novel Paclitaxel-Epothilone Hybrids, manuscript in preparation.
3. Ojima, I.; Inoue, T.; Chakravarty, S. (1999) Enantiopure Fluorine-Containing Taxoids: Potent Anticancer Agents and Useful Probes for Biomedical Problems. J. Fluorine Chem., in press. (special issue commemorating Professor Yoshiro Kobayashi's 75th birthday).
4. Ojima, I.; Inoue, T.; Slater, J. C.; Lin, S.; Kuduk, S. C.; Chakravarty, S.; Walsh, J. J.; Gilchrist, L.; McDermott, A. E.; Cresteil, T.; Monsarrat, B.; Pera, P.; Bernacki, R. J. Synthesis of Enatiopure F-Containing Taxoids and Their Use as Anticancer Agents as well as Probes for Biomedical Problems. ACS Book Series,in press.
5. Ojima, I.; Kuduk, S. D.; Chakravarty, S. (1998) Recent Advances In The Medicinal Chemistry Of Taxoid Anticancer Agents, Adv. Med. Chem., in press.
6. Ojima, I.; Lin, S.; Chakravarty, S.; Fenoglio, I.; Park, Y. -H.; Sun, C. -M.; Appendino, G.; Pera, P.; Veith, J. M.; Bernacki, R. J. (1998) Synthesis and Structure-Activity Relationships of Novel Nor-seco Taxoid Analogs. J. Org. Chem.1998, 63, 1637-1645.
7. Chakravarty, S.; Roy, N. K. (1998) Synthesis and Herbicidal Activity of Amides of 1,1-Dichloroethyl Phosphonic Acid and their Structure-Activity Relationships, manuscript in preparation.
8. Chakravarty, S.; Roy, N. K. (1998) QSAR and 3-D COMFA studies of phosphonic acid-based crop protection agents, manuscript in preparation.
9. Ojima, I.; Kuduk, S. D.; Chakravarty, S; Ourevitch, M.; Bégué J.-P. (1997) A Novel Approach to the Study of Solution Structures and Dynamic Behavior of Paclitaxel and Docetaxel Using Fluorine-Containing Analogs as Probes, J. Am. Chem. Soc., 119, 5519-5527.
10. Chakravarty, S.; Q. Dong; I. Ojima. (1996) New RGD Peptide Mimetics as Efficient Inhibitors of Platelet Aggregation, In "The Peptides - Chemistry and Biology"; Proceedings of Fourteenth American Peptide Symposium; P. T. P. Kaumaya and R. S. Hodges (Eds.): ESCOM Science Publisher: pp 325-327.
11. Ojima, I.; Chakravarty, S.; Dong, Q.; Peerschke, E.I.; Hwang, S. M.; Wong, A. S. (1996) Design, Synthesis and Structure-Activity Relationships of New RGD Peptide Mimetics as Potent Antagonists of GPIIb/IIIa Receptor, In "The Peptides - Chemistry and Biology"; Proceedings of Fourteenth American Peptide Symposium; P. T. P. Kaumaya and R. S. Hodges (Eds.): ESCOM Science Publisher (1996): pp 851-852.
12. Ojima, I.; Kuduk, S. D.; Slater, J. C.; Gimi, R. H.; Sun, C. M.; Chakravarty, S.; Ourevitch, M.; Abouabdellah, A.; Bonnet-Delpon, D.; Bégué, J.-P.; Veith, J. M.; Pera, P.; Bernacki, R. J. (1996) Synthesis, Biological Activity, and Conformational Analysis of Fluorine-Containing Taxoids, In "Biomedical Frontiers of Fluorine Chemistry", I. Ojima, J. McCarthy, and J. T. Welch (Eds..), ACS Symp. Series 639, The American Chemical Society, Washington, D. C; Chapter 17, pp 228-243.
13. Ojima, I.; Chakravarty, S.; Dong, Q. (1995) Antithrombotic agents: From RGD to peptide mimetics. Bioorg. Med. Chem., 3, 337-360.
14. Ojima, I.; Dong, Q.; Chakravarty, S.; Peerschke, E.; Hwang, S. M.; and Wong, A. S. (1995) Design and Synthesis of RGD Peptide Hybrids as Highly Efficient Inhibitors of Platelet Aggregation, Bioorg. Med. Chem. Lett., 5, 1941-1946.
15. Ojima, I.; Dong, Q.; Chakravarty, S. (1994) Platelet Aggregation Inhibitory Agents: From RGD to Peptide Mimetics. J. Synth. Org. Chem., Jpn., 52, 413-425.
16. Chakravarty, S.; Tomar, S.S. (1990) Synthesis and Fungitoxicity
of Some Triaryl Ethers from a-HCH. Pesticide Research Journal, 2,
11-15.
PRESENTATIONS
1. Chakravarty, S.; Fumero Oderda, C. L.; Bounaud, P. -Y.; Pera, P.; Bernacki, R. J.; Ojima, I. Design and Synthesis of Potent Multidrug Resistance Reversal Agents for Cancer Cells. 217th American Chemical Society National Meeting, March 24-29, 1999, Anaheim, CA; Abstr. MEDI XXX.
2. Chakravarty, S.; Inoue, T.; Lin, S.; Horwitz, S. B.;
Kuduk, S. D.; Danishefsky, S. J.; Ojima, I. A Common Pharmacophore
for
Cytotoxic Natural Products that Stabilize Microtubules. 217th
American Chemical Society National Meeting, March 24-29, 1999, Anaheim,
CA; Abstr. MEDI XXX.
3. Lin, S.; Inoue, T.; Chakravarty, S.; Ojima, I. Design and Synthesis of Novel Hybrid Constructs Based on the Common Pharmacophore for Microtubule-Stabilizing Agents. 217th American Chemical Society National Meeting, March 24-29, 1999, Anaheim, CA; Abstr. MEDI XXX.
4. Lin, S.; Inoue, T.; Chakravarty, S.; Ojima, I. Design and Synthesis of Taxoid-Epothilone Hybrids. Part I. 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORGN 464.
5. Inoue, T.; Lin, S.; Walsh, J. J.; Borella, C.; Chakravarty, S.; Ojima, I. Design and Synthesis of Taxoid-Epothilone Hybrids. Part II. 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORGN380.
6. Lin, S.; Inoue, T.; Borella, C.; Walsh, J. J.; Chakravarty, S.; Ojima, I. "Design and Structure-Activity Relationship Study of Taxoid-Epothilone Hybrids." 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. MEDI 313.
7. Chakravarty, S.; Ojima, I. (1997) Taxoid and Non-taxoid Inhibitors of Microtubule Disassembly: A Molecular Modeling Approach to the Elucidation of a Common Pharmacophore. 214th American Chemical Society National Meeting, September 7-12, Las Vegas, NV; Abstr. MEDI 75.
8. Chakravarty, S.; Dong, Q.; Pollina, E.; Ojima, I. (1996) Design and Synthesis of RGD Peptide Mimetics As Potent and Selective GPIIb/IIIa Antagonists. The New York Academy of Sciences Poster Session, November 2. New York City, NY, USA.
9. Wang, T.; Bhave, G.; Delaloge, F.; Chakravarty, S.; Ojima, I. (1996) Synthesis of Carbocyclic Peptidomimetic Skeleton for GPIIb/IIIa Antagonists. The New York Academy of Sciences Poster Session, November 2. New York City, NY, USA.
10. Slater, J.; Kuduk, S. D.; Ojima, I.; Chakravarty, S.; Pera, P.; Veith, J. M.; Bégué, J.-P.; R. J. Bernacki (1996) The New York Academy of Sciences Poster Session, November 2. New York City, NY, USA.
11. Kuduk, S. D.; Chakravarty, S.; Ojima, I.; Ourevitch, M.; Bégué, J. -P. (1995) Conformational Analysis Study of Novel Taxoids. 210th American Chemical Society National Meeting, August 20-24. Chicago, Illinois, USA.
12. Chakravarty, S.; Dong, Q.; Ojima, I. (1995) New RGD Mimetics as Efficient Inhibitors of Platelet Aggregation. Fourteenth American Peptide Symposium. June 17-23. Columbus, Ohio, USA.
13. Dong, Q.; Chakravarty, S.; Ojima, I. (1994) New RGD Peptide
Mimetics as Efficient Inhibitors of Platelet Aggregation.
208th American
Chemical Society National Meeting, August 21-25, Washington D.C.; Abstracts
MEDI
60.
SUBRATA CHAKRAVARTY
Work Address:
Department of Chemistry
State University of New York at Stony Brook
Stony Brook, NY 11794-3400
Tel.: (516) 632-7939; Fax: (516) 632-7942
e-mail: schakravarty@sbchem.sunysb.edu