TAO WANG
Ph.D., 1999
EDUCATION
1994 - Present Ph. D. candidate, Organic/Medicinal Chemistry, State University of New York at Stony Brook, Stony Brook, New York.
Advisor: Dr. Iwao Ojima
1989 - 1994 B. Sc., Polymer Chemistry, University of Science and Technology of China (USTC), Hefei, Anhui, P. R. China.
RESEARCH INTERESTS
• Design and syntheses of compounds of medicinal importance including antitumor/antiviral agents.
RESEARCH PROJECTS
• Asymmetric syntheses of dipeptide isosteres via b-Lactam Synthon Method as building blocks for HIV-1 protease inhibitors and renin inhibitors.
• Syntheses and structure-activity relationship studies of C-2' substituted taxoids as potential anticancer agents.
• Asymmetric syntheses of multifunctionalized g/d lactones/lactams and sugars/aza-(amino)sugars via ring expansions of b-lactams (solution and solid phase).
• Syntheses of new Positron Emission Tomography (PET) ligands for mapping nicotinic acetylcholine receptors (collaboration with Dr. Fowler's group at Brookhaven National Laboratory).
• Syntheses and biological activity of advanced second-generation taxoids.
WORK/RESEARCH EXPERIENCE
1996 - present Graduate Research Assistant, Department of Chemistry, SUNY at Stony Brook.
1995 - 1996 Teaching Assistant, SUNY at Stony Brook (Organic Chemistry).
1994 - 1995 Teaching Assistant, SUNY at Stony Brook (General Chemistry).
1993 - 1994 Undergraduate Research Assistant, USTC, P. R. China.
AWARDS/AFFILIATIONS
1998 - present Member, American Pharmaceutical Association (APhA).
1998 - present Member, American Peptide Society (APS).
1998 - present Member, American Association for the Advancement of Science (AAAS).
1994 - present Member, American Chemical Society (ACS).
1997 Mitsubishi Travel Award.
1990 - 1993 Outstanding Student Scholarships, USTC, China.
SKILLS
• Organic synthesis (including asymmetric and catalytic transformations).
• Experienced in the operation of high field NMR spectrometers (Bruker and Varian) and FT-IR.
• Experienced in the use of various analytical equipment (HPLC, GC).
• Familiar with Molecular Modeling (Sybyl, Macspartan, Chem3D).
• Extensive database search using Beilstein, SciFinder.
PUBLICATIONS
1. Ojima, I.; Wang, T.; Lin, S.; Bounaud, P-Y. "New And Efficient Route to Poly- functionalized Heterocycles. Stereocontrolled Syntheses of g(d)-Lactones/Lactams" manuscript in preparation.
1. Ojima, I.; Wang, T.; Delaloge, F. "Extremely Stereoselective Alkylation of 3-Siloxy-beta- lactams and Its Applications to the Asymmetric Syntheses of Novel 2-Alkylisoserines, Their Dipeptides, and Taxoids" Tetrahedron Lett. 1998, 39, 3663-3666.
2. Ojima, I.; Wang, H.; Wang, T.; Ng, E. W. "New Approaches to the Asymmetric Syntheses of Dipeptide Isosteres via b-Lactam Synthon Method" Tetrahedron Lett. 1998, 39, 923-926.
PRESENTATIONS
1. Wang, T.; Bounaud, P-Y.; Lin S.; Ojima, I. "New And Efficient Route to Polyfunctionalized Heterocycles. I. Stereocontrolled Syntheses of g(d)-Lactams", 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORG 559.
2. Lin, S.; Wang, T.; Ojima, I. "New And Efficient Route to Polyfunctionalized Heterocycles. II. Stereocontrolled Syntheses of g(d)-Lactones", 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, Massachusetts; Abstr. ORG 560.
3. Wang, T.; Delaloge, F.; Ojima, I. "Extremely Stereoselective Alkylations of beta-Lactams and Their Applications to the Asymmetric Synthesis of 2-Alkylisoserines and New Taxoids", 214th American Chemical Society National Meeting, September 7-11, 1997, Las Vegas, Nevada; Abstr. ORG 210.
4. Ojima, I.; Wang, H.; Wang, T.; Ng, E. W. "New Approaches to the Asymmetric Syntheses of Dipeptide Isosteres via beta-Lactam Synthon Method", 213th American Chemical Society National Meeting, April 13-17, 1997, San Francisco, CA; Abstr. ORG 052.
5. Wang, T.; Bhave, G.; Delaloge, F.; Chakravarty, S.; Ojima, I. "Synthesis of Carbocyclic Peptidomimetic Skeleton for GPIIb/IIIa Antagonists", New York Academy of Sciences Poster Program for Graduate Students of Chemistry, November 2, 1996; New York City, New York.
Work Address:
Department of Chemistry
State University of New York at Stony Brook
Stony Brook, NY 11794-3400
Phone: (516) 632-7939; Fax: (516) 632-7942
e-mail: tawang@ccmail.sunysb.edu